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Substrati Specifici di Protein Kinase (1mg, 3mg)

code substrate protein kinase
PKA-001 LRRASLG PKA (1)

PKC-002 QKRPSQRSKYL PKC(2)

AKT-003 RPRAATF Akt/PKB(3)

CDC-004 Ac-SPGRRRRK CDC2 (4)

CK1-005 RRKDLHDDEEDEAMSITA CK1 (5)

CK2-006 RRRADDSDDDDD CK2(6)

CK2-007 MSGDEMIFDPTMSKKKKKKKKP CK2(7)holoenzyme


DIR-008 KKISGRLSPIMTEQ DYRK(8)

GSK-009 YRRAAVPPSPSLSRHSSPHQpSEDEEE
GSK3α,β(9)

AUR-0010 YALKRASLGAA
Aurora-A(10)

PIM-0011 ARKRRRHPSGPPTA
PIM


 

Cell Penetrating Peptides (1mg, 3mg)

code sequence name
PEN-001 RQIKIWFQNRRMKWKK-NH2 Penetratin (11)
TAT-001 GRKKRRQRRRPPQ-NH2 HIV-TAT[48-60] (12)
TAT-002 GYGRKKRRQRRRG-NH2 HIV-TAT[G-47-57-G] (12)
R9-001 RRRRRRRRR ARG9 Peptide
BUF-001 TRSSRAGLQFPVGRVHRLLRK Buforina
MAST-001 INLKALAALAKKIL-NH2 Mastoparan Peptide
TRAS-001 GWTLNSAGYLLGKINLKALAALAKKIL Transportan Peptide

 

References:

1) Maller JL, Kemp BE, Krebs EG (1978) “In vivo phosphorylation of a synthetic peptide substrate of cyclic AMP-dependent protein kinase.” Proc Natl Acad Sci U S A. 75(1):248-51.

2) Yasuda I, Kishimoto A, Tanaka S, Tominaga M, Sakurai, Nishizuka Y (1990) A synthetic peptide substrate for selective assay of protein kinase C. Biochem Biophys Res Commun 166:1220-7.

3) Alessi DR, Caudwell FB, Andjelkovic M, Hemmings BA, Cohen P (1996) Molecular basis for the substrate specificity of protein kinase B: comparison with MAPKAP kinase-1 and p70 S6 kinase. FEBS Lett 399:333-8.

4) Srinivasan J, Koszelak M, Mendelow M, Kwon YG, Lawrence DS (1995) The design of peptide-based substrates for cdc2 protein kinase. Biochem J 309 (Pt 3): 927-31.

5) Marin O, Meggio F, Pinna LA (1994) Design and synthesis of two new peptide substrates for the specific and sensitive monitoring of casein kinase-1 and-2. Biochem Biophys Res Commun 198: 898-905.

6) Meggio F, Marin O, Pinna LA. (1994) Substrate specificity of protein kinase CK2. Cell Mol Biol Res 40, 401-9

7) Salvi M, Sarno S, Marin O, Meggio F, Itarte e, Pinna LA (2006) Discrimination between the activity of protein kinase CK2 holoenzyme and its catalytic subunits FEBS LETT 580 (16): 3948-3952 JUL 10 2006

8) G Woods YL, Rena G, Cohen P et al. (2001) "The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site" Biochem J. 355(Pt 3):597-607

9) H Sutherland C, Leighton IA, Cohen P (1993) Inactivation of glycogen synthase kinase-3 beta by phosphorylation: kinase connection in insulin and growth factor signalling. Biochem J 296 (Pt 1):15-9.

10) Ferrari S, Marin O, Pagano Ma, Meggio F, Hess D, El-Shemerly M, Krystyniak A, Pinna La Aurora-A site specificity: a study with synthetic peptide substrates Biochem J 390: 293-302Part 1 Aug 15 2005

11) Y-H. Chiu, C Alvarez-Baron, E. Y. Kim and S. E. Dryer. 2010. Dominant-Negative Regulation of Cell Surface Expression by a Pentapeptide Motif at the Extreme COOH Terminus of an Slo1 Calcium-Activated Potassium Channel Splice Variant. Molecular Pharmacology 2010 vol. 77 no. 4 497-507

12) S. Sandgren, F. Cheng, M. Belting. 2002. Nuclear Targeting of Macromolecular Polyanions by an HIV-Tat Derived Peptide. J. Biol. Chem. 2002 Vol. 277, No. 41, pp. 38877-38883


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